The Effect of Promoters and Inhibitors on the Rheology of Coagulating Blood
Location: Bayswater, VIC
Duration: 4-5 months negotiable
Keywords: Blood, Coagulation, Biochemistry, Biomedical research
Haemograph is a biomedical start-up company based in Victoria. We are developing a novel device to measure properties of coagulating blood.
One area of interest to us is to understand the effect of different reagents acting as promoters or inhibitors on the rheology of blood during coagulation. We are particularly interested in what the effect of these reagents on the rheology tells us about the different pathways during blood coagulation.
The aim of this project is to identify the effect of various reagents that act as promoters or inhibitors on the transient rheology of blood during coagulation. Objectives include identifying target reagents to assess the various pathways and determining (based on calculations and literature) appropriate dosages for each. IF time allows, there will also be the opportunity to conduct experiments to assess the quantitative effect of the reagent on the rheology of blood.
Successful completion of this project will increase the effectiveness of Haemograph’s device and potentially increase the range of diseases the device can identify and the number of people that we can help.
This project is appropriate for a biomedical, biology or biochemical researcher or equivalent with an interest in, and good understanding of, blood.
Experience in rheology is not expected.
Research to be Conducted
- Prepare a review synthesising information from the literature and other sources to identify target reagents for further analysis
- Determine candidate reagents and appropriate concentrations for further investigation
- Calculate the quantitative effect of different reagents on blood rheology
- Develop appropriate testing protocols
- Perform rheological experiments (full training will be provided in the use of the equipment)
For this project, we are looking for a PhD student with the following skills:
- Ability to synthesise literature and other information sources
- Excellent understanding of blood coagulation and underlying pathways
- Excellent written communication skills
- Excellent record-keeping skills
- Ability to operate safely in a lab environment
- Ability to work without the need for close supervision
Subject to negotiation and the intern’s progress the expected and desired outcomes include:
1) A scoping study identifying priority reagents and concentrations
2) A detailed work-plan (including concentrations of reagents and the required materials) and testing protocols for assessing the effect of reagent concentration on blood rheology
3) The results of the effect of the reagent concentration on various aspects of the blood coagulation process as identified by the rheology
As a note, we do not expect the intern to complete all (or, depending on progress, even any) of the experimental projects in outcome 3. There will be encouragement for the intern to publish results in appropriate peer-reviewed journals in conjunction with academic and industry mentors.
The intern will receive $3,000 per month of the internship, usually in the form of stipend payments.
It is expected that the intern will primarily undertake this research project during regular business hours, spending at least 20% of their time on-site with the industry partner. The intern will be expected to maintain contact with their academic mentor throughout the internship either through face-to-face or phone meetings as appropriate.
The intern and their academic mentor will have the opportunity to negotiate the project’s scope, milestones and timeline during the project planning stage.
To participate in the APR.Intern program, all applicants must satisfy the following criteria:
- Be a PhD student currently enrolled at an Australian University.
- PhD candidature must be confirmed.
- Applicants must have the written approval of their Principal Supervisor to undertake the internship. This approval must be submitted at the time of application.
- Internships are also subject to any requirements stipulated by the student’s and the academic mentor’s university.
Wednesday 4 April 2018
INT – 0359